LymphedemaV1, Main, Exploration, bibRecord, 001243

Connexins and their channels in inflammation

Identifieur interne : 001243 ( Main/Exploration ); précédent : 001242; suivant : 001244

Connexins and their channels in inflammation

Auteurs : Joost Willebrords ; Sara Crespo Yanguas ; Michaël Maes ; Elke Decrock [Belgique] ; Nan Wang [Belgique] ; Luc Leybaert [Belgique] ; Brenda R. Kwak [Suisse] ; Colin R. Green ; Bruno Cogliati [Brésil] ; Mathieu Vinken

Source :

Critical reviews in biochemistry and molecular biology [ 1040-9238 ] ; 2016.

RBID : PMC:5584657

Abstract

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration. Despite the wealth of knowledge regarding the involvement of cellular communication in inflammation, studies on the role of connexin-based channels in this process have only begun to emerge in the last few years. In this paper, a state-of-the-art overview of the effects of inflammation on connexin signaling is provided. Vice versa, the involvement of connexins and their channels in inflammation will be discussed by relying on studies that use a variety of experimental tools, such as genetically modified animals, small interfering RNA and connexin-based channel blockers. A better understanding of the importance of connexin signaling in inflammation may open up towards clinical perspectives.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584657

DOI: 10.1080/10409238.2016.1204980
PubMed: 27387655
PubMed Central: 5584657

Affiliations:

Le document en format XML

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<author><name sortKey="Willebrords, Joost" sort="Willebrords, Joost" uniqKey="Willebrords J" first="Joost" last="Willebrords">Joost Willebrords</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
<wicri:noCountry code="subfield">Sara Crespo Yanguas: Tel: +32 2 477 45 87</wicri:noCountry>
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<author><name sortKey="Crespo Yanguas, Sara" sort="Crespo Yanguas, Sara" uniqKey="Crespo Yanguas S" first="Sara" last="Crespo Yanguas">Sara Crespo Yanguas</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
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<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
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<orgName type="university">Université de Genève</orgName>
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<author><name sortKey="Green, Colin R" sort="Green, Colin R" uniqKey="Green C" first="Colin R." last="Green">Colin R. Green</name>
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<orgName type="university">Université de São Paulo</orgName>
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 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
<wicri:noCountry code="subfield">Sara Crespo Yanguas: Tel: +32 2 477 45 87</wicri:noCountry>
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 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
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<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
<wicri:noCountry code="subfield">Sara Crespo Yanguas: Tel: +32 2 477 45 87</wicri:noCountry>
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<author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michaël" last="Maes">Michaël Maes</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
<wicri:noCountry code="subfield">Sara Crespo Yanguas: Tel: +32 2 477 45 87</wicri:noCountry>
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<author><name sortKey="Decrock, Elke" sort="Decrock, Elke" uniqKey="Decrock E" first="Elke" last="Decrock">Elke Decrock</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
<orgName type="university">Université de Gand</orgName>
<country>Belgique</country>
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<region type="district" nuts="2">Province de Flandre-Orientale</region>
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<author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
<orgName type="university">Université de Gand</orgName>
<country>Belgique</country>
<placeName><settlement type="city">Gand</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province de Flandre-Orientale</region>
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</affiliation>
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<author><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
<orgName type="university">Université de Gand</orgName>
<country>Belgique</country>
<placeName><settlement type="city">Gand</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province de Flandre-Orientale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R." last="Kwak">Brenda R. Kwak</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Pathology and Immunology and Division of Cardiology, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland; Brenda R. Kwak: Tel: +41 22 379 57 37</nlm:aff>
<orgName type="university">Université de Genève</orgName>
<country>Suisse</country>
<placeName><settlement type="city">Genève</settlement>
<region nuts="3" type="region">Canton de Genève</region>
</placeName>
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</author>
<author><name sortKey="Green, Colin R" sort="Green, Colin R" uniqKey="Green C" first="Colin R." last="Green">Colin R. Green</name>
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</affiliation>
</author>
<author><name sortKey="Cogliati, Bruno" sort="Cogliati, Bruno" uniqKey="Cogliati B" first="Bruno" last="Cogliati">Bruno Cogliati</name>
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<orgName type="university">Université de São Paulo</orgName>
<country>Brésil</country>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vinken, Mathieu" sort="Vinken, Mathieu" uniqKey="Vinken M" first="Mathieu" last="Vinken">Mathieu Vinken</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
 Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
<wicri:noCountry code="subfield">Sara Crespo Yanguas: Tel: +32 2 477 45 87</wicri:noCountry>
</affiliation>
</author>
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<front><div type="abstract" xml:lang="en"><p id="P1">Inflammation may be caused by a variety of factors and is a hallmark of a
plethora of acute and chronic diseases. The purpose of inflammation is to
eliminate the initial cell injury trigger, to clear out dead cells from damaged
tissue and to initiate tissue regeneration. Despite the wealth of knowledge
regarding the involvement of cellular communication in inflammation, studies on
the role of connexin-based channels in this process have only begun to emerge in
the last few years. In this paper, a state-of-the-art overview of the effects of
inflammation on connexin signaling is provided. <italic>Vice versa</italic>, the
involvement of connexins and their channels in inflammation will be discussed by
relying on studies that use a variety of experimental tools, such as genetically
modified animals, small interfering RNA and connexin-based channel blockers. A
better understanding of the importance of connexin signaling in inflammation may
open up towards clinical perspectives.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
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</country>
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<name sortKey="Green, Colin R" sort="Green, Colin R" uniqKey="Green C" first="Colin R." last="Green">Colin R. Green</name>
<name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michaël" last="Maes">Michaël Maes</name>
<name sortKey="Vinken, Mathieu" sort="Vinken, Mathieu" uniqKey="Vinken M" first="Mathieu" last="Vinken">Mathieu Vinken</name>
<name sortKey="Willebrords, Joost" sort="Willebrords, Joost" uniqKey="Willebrords J" first="Joost" last="Willebrords">Joost Willebrords</name>
</noCountry>
<country name="Belgique"><region name="Région flamande"><name sortKey="Decrock, Elke" sort="Decrock, Elke" uniqKey="Decrock E" first="Elke" last="Decrock">Elke Decrock</name>
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<name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name>
<name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name>
</country>
<country name="Suisse"><region name="Canton de Genève"><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R." last="Kwak">Brenda R. Kwak</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Cogliati, Bruno" sort="Cogliati, Bruno" uniqKey="Cogliati B" first="Bruno" last="Cogliati">Bruno Cogliati</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Connexins and their channels in inflammation

Connexins and their channels in inflammation

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